Preventing Infections in Cancer Patients

Cancer and chemotherapy can damage the immune system, reducing your number of infection fighting white blood cells and making it harder for your body to fight off infections. One out of every 10 cancer patients who receives chemotherapy gets an infection that requires a hospital visit. Garden City Hospital physicians are here to help you take the proper steps to prevent infection.


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Cancer patients receiving chemotherapy are more likely to get an infection. For these people, any type of infection may become serious quickly. If you have cancer and are receiving chemotherapy, learn the facts about infection.

Cancer patients who are treated with chemotherapy are more likely to get infections through everyday activities with their family and friends, or from health care settings. One out of every 10 cancer patients who receives chemotherapy gets an infection that requires a hospital visit.

What Is an Infection?

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You get an infection when germs enter your body and multiply, causing illness, organ and tissue damage, or disease. Bacteria and viruses cause infections.

How Does the Body Normally Fight Infections?

The immune system helps your body protect itself from getting an infection. Cancer and chemotherapy can damage this system, reducing your numbers of infection-fighting white blood cells and making it harder for your body to fight infections.

How Can I Prevent Infections During Chemotherapy?

Prepare: Watch Out for Fever

If you get a fever during your chemotherapy treatment, it’s a medical emergency. Fever may be the only sign that you have an infection, and an infection during chemotherapy can be life-threatening.

You should take your temperature any time you feel warm, flushed, chilled, or not well. If your temperature is 100.4°F (38°C) or higher for more than one hour, or 101°F (38.3°C) or higher for any length of time, call your doctor right away, even if it happens in the middle of the night. You should also—

  • Find out from your doctor when your white blood cell count is likely to be the lowest, since this is when you’re most at risk for infection.
  • Keep a working thermometer in a convenient location and know how to use it.
  • Keep your doctor’s phone numbers with you at all times. Make sure you know what number to call when their office is open and closed.
  • If you have to go to the emergency room, tell the person checking you in that you are a cancer patient undergoing chemotherapy. If you have a fever, you might have an infection. This is a life-threatening condition, and you should be seen quickly.

Prevent: Clean Your Hands

Clean hands help prevent infections. Many diseases are spread by not cleaning your hands, which is especially dangerous when you’re getting chemotherapy treatment because your body may not be able to fight off infections like it used to. You and anyone who comes around you, including all members of your household, your doctors, and nurses, should clean their hands frequently. Don’t be afraid to ask people to clean their hands. Use soap and water to wash your hands. If soap and water aren’t available, use an alcohol-based hand sanitizer.

Be sure to clean your hands—

Photo: Washing hands
  • Before, during, and after cooking food.
  • Before you eat.
  • After going to the bathroom.
  • After changing diapers or helping a child use the bathroom.
  • After blowing your nose, coughing, or sneezing.
  • After touching or cleaning up after your pet.
  • After touching trash.
  • Before and after treating a cut or wound or caring for your catheter, port, or other access device.

Protect: Know the Signs and Symptoms of Infection

During your chemotherapy treatment, your body may not be able to fight off infections like it used to. When your white blood cell counts are low, you must take infection symptoms seriously. Infection during chemotherapy can lead to hospitalization or death. Call your doctor right away if you notice any of the following signs and symptoms of an infection—

  • Fever (this is sometimes the only sign of an infection).
  • Chills and sweats.
  • Change in cough or a new cough.
  • Sore throat or new mouth sore.
  • Shortness of breath.
  • Nasal congestion.
  • Stiff neck.
  • Burning or pain with urination.
  • Unusual vaginal discharge or irritation.
  • Increased urination.
  • Redness, soreness, or swelling in any area, including surgical wounds and ports.
  • Diarrhea.
  • Vomiting.
  • Pain in the abdomen or rectum.
  • New onset of pain.

Find out from your doctor when your white blood cell count is likely to be the lowest, since this is when you’re most at risk for infection. This usually occurs between 7 and 12 days after you finish each chemotherapy dose, and may last up to one week.

What Should I Do If I Think I Have an Infection?

Call your doctor right away, even if this happens in the middle of the night. This is considered an emergency. Don’t wait until morning. Keep your doctor’s phone numbers with you at all times. Make sure you know what number to call during your doctor’s office hours, as well as after hours.

What CDC Is Doing

Preventing Infections in Cancer Patients is a comprehensive program focused on providing information, action steps, and tools to help reduce the risk of developing potentially life-threatening infections during chemotherapy treatment. Through the program, CDC developed the following tools—

More Information

For Patients and Caregivers

For Health Care Providers

Content provided and maintained by the US Centers for Disease Control and Prevention (CDC). Please see our system usage guidelines and disclaimer.